dementia neuropsychiatric symptoms
Conditions
Interventions
Randomization to discontinuation (n=246) or continuation (n=246) of
antihypertensive treatment during 8 months. Discontinuation of antihypertensive
treatment aims to achieve a systolic blood pressur
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Eligible to participate in this study, a subject must meet all of the following criteria: • being admitted in nursing home • have a diagnosis of moderate to severe dementia according to the Reisberg Global Deterioration Scale (score 5-6-7) • are currently on antihypertensive treatment with a calcium antagonist, diuretic, ACE-inhibitor, beta-blocker or angiotensin-II-receptor blocker prescribed for hypertension • have a systolic blood pressure
Exclusion criteria
Exclusion criteria: An potential subject who meets any of the following criteria will be excluded from participation: • recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The co-primary outcome measures are the differences in change of scores between 0 and 4 months on the Neuropsychiatric Inventory - Nursing Homes (NPI-NH) and quality of life (Qualidem). Long-term effects on primary and secondary outcomes will be analysed over 8 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include NPS registered in the medical records, care dependency, cognitive function, general daily functioning, care-related quality of life, orthostatic hypotension, incident falls, and psychotropic medication use. Long-term effects on primary and secondary outcomes will be analysed over 8 months. In addition, cost-effectiveness will be evaluated. | — |
Countries
Netherlands
Outcome results
None listed