anabole resistentie muscle growth muscle protein synthesis
Conditions
Interventions
A 8-week passive heat treatment (PHT) intervention at the department of Human
Biology, Maastricht University. The PHT intervention will consist of 3 times
per week (~45min per session) sitting in a
Sponsors
Universiteit Maastricht
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers between the age 65 and 85 years
Exclusion criteria
Exclusion criteria: • Allergy for one of the food items used • >5% weight change in the previous 6 months • Participating in a structured (progressive) exercise program • Frequent (more than once per week) user of infrared (or traditional) sauna in the past 3 months • Smoking • Diagnosed cardiovasular disease • Diagnosed musculoskeletal, GI tract, metabolic (e.g. diabetes) or pulmonary (e.g. COPD) disorders • Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories). • Chronic use of gastric acid suppressing medication and/ or anti-coagulants • Recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional synthetic rate (FSR) of muscle protein synthesis (MPS) over the 4 hour period following meal ingestion | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint is the skeletal muscle microvascular perfusion capacity in rest and 1h following meal ingestion assessed by contrast enhanced ultrasound. change in post-prandial plasma amino acid, glucose and insulin concentration. Changes in type I and type II muscle fiber capillarization assessed in the post-absorptive muscle biopsy samples by the use of immunohistochemistry | — |
Countries
Netherlands
Outcome results
None listed