acidosis diabetic ketoacidosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18 to 75 years - T1DM, diagnosed prior to admission (the T1DM diagnosis should be based upon the presence of (i) hyperglycemia (fasting glucose levels >7.0 mmol/L or random glucose levels >11.1 mmol/L), (ii) c-peptide levels of less than 0.2 nmol/L and (iii) presence of auto-immunity (anti-GAD, anti-islet auto-antibodies and/or zinc receptors)) - DKA defined as • Blood glucose levels >15mmol/L • Presence of urine ketones • pH levels
Exclusion criteria
Exclusion criteria: - Pregnancy (actual or planned) - Known underlying condition in which phosphate metabolism is altered, including hyperparathyroidism, vitamin D deficiency, Fanconi syndrome, chronic diarrhoea, and use of medication with hypophosphatemia as a side-effect, such a pamidronic acid or ferric carboxymaltose - Inability or unwillingness to meet the protocol requirements - Any severe or uncontrolled medical or psychological condition which, in the opinion of the investigator, would compromise the ability to meet protocol requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the association between FGF23 and phosphate during treatment for DKA corrected for follow-up time. Time course analyses will be performed to gain insight in the sequence of events and potential causal relationships. Furthermore, consequences of hypophosphatemia in cellular energy state will be addressed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include markers of oxidative stress, mitochondrial dysfunction and cellular senescence. | — |
Countries
Netherlands
Outcome results
None listed