Het onderzoek wordt bij gezonde mensen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor therapeutische interventies voor patiënten met verlate slaap-fase syndroom of seizoensgebonden depressie. Not applicable
Conditions
Interventions
The intervention consists of a conditioning paradigm, in which as association
is learned between a scent and the circadian CAR. See Study design of the
summary for the description of this paradigm.
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male gender * Aged between 21 and 34 years of age * Good understanding of written and spoken Dutch.
Exclusion criteria
Exclusion criteria: * Refusal to give written informed consent * Severe somatic or psychiatric conditions that would adversely affect participant*s safety or that might interfere with the study protocol * Olfactory impairments * Known sensitivity or hypervigilance to one of the ingredients of the scents used in this experiment * Heavy use of (illegal) drugs including cannabis and habits of heavy drinking * Irregular sleep pattern or sleep problems * Use of medication that interferes with the study protocol * Factors known to influence the CAR: o Having an acute illness, or experienced an illness in the past seven days (e.g. influenza, common cold) o Experienced jet lag or shift work in the past seven days o Use of (oral) glucocorticoid medication o HPA-axis related endocrine disorders (e.g., Cushings disease or Addisons disease) o Brain damage, particularly hippocampal brain damage o Obesity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is change in the CAR (evocation measurement compared to baseline measurement) in the experimental compared with the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are physiological parameters (e.g. HR), and psychological parameters (e.g. affect). | — |
Countries
Netherlands
Outcome results
None listed