obsessive-compulsive disorder
Conditions
Interventions
The patients are treated with deep brain stimulation.
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: We will include patients who meet the following inclusion criteria: - Obsessive compulsive disorder according to DSM-5 criteria - At least one of the following conditions is met: 1) Y-BOCS score >= 28; 2) Y--BOCS >= 14 in case of solely obsessions or compulsions; 3) Suffering from obsessions or compulsions for at least 8 hours a day (i.e. a score of 4 on item 1 or item 6 of the Y-BOCS) - Treatment refractoriness is defined as failure of all of the following: 1) at least 2 different types of SSRI*s; 2) clomipramine; 3) addition of an antipsychotic to either an SSRI or clomipramine; 4) an adequate trial of cognitive-behavorial therapy given by a therapist who has experience with OCD; all treatments should be given at therapeutic dosages for adequate duration. On clinical grounds, exceptions to this definition are allowed, but only after consultation with the coordinating center. - Age: 18 years or older - Motivated and capable to make the frequent visits to the outpatient clinic, which are necessary for parameter optimization and the CBT. - Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion
Exclusion criteria
Exclusion criteria: - Primary diagnosis in psychotic spectrum - Unstable multiple sclerosis (MS) - Acute brain damage (eg. recent hemorrhage or stroke) - General contraindications to have surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in obsessive-compulsive symptomes (measured as a change of Y-BOCS score compared to baseline) | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive symptoms (measured with the Hamilton Depression Rating Scale) Adverse events DBS settings Medication use | — |
Countries
Netherlands
Contacts
Public ContactR.J.T. Mocking
Amsterdam UMC
Outcome results
None listed