Change of cognitive function and brain structure in long-term breast cancer survivors

Change of cognitive function and brain structure in long-term breast cancer survivors - Cognitive function in breast cancer survivors

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50155

Enrollment

120

Registered

2020-05-06

Start date

2020-06-28

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive deficits memory and concentration problems

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Breast cancer survivors who participated in our previous study (NL18761.031.07). Inclusion criteria in our previous study were: female treatment with adjuvant CMF chemotherapy for breast cancer between 1975 and 1995 age between 50 and 80 years sufficient proficiency in Dutch language

Exclusion criteria

Exclusion criteria: No exclusion criteria will be applied for the current study. For our previous study the following exclusion criteria were applied: use of endocrine therapy contra-indications for MRI scan tumor relapse metastases second primary tumor

Design outcomes

Primary

Measure	Time frame
1. The difference in change over time of cognitive function between breast cancer survivors and cancer-free individuals 2. The difference in change over time of brain MRI measurements between breast cancer survivors and cancer-free individuals	—

Secondary

Measure	Time frame
1. The difference in change of subjective memory complaints between breast cancer survivors and cancer-free individuals 2. The predictive value of cognitive function at the first assessment for cognitive function at follow-up measurement among breast cancer survivors 3. The predictive value of subjective memory complaints at the first assessment predict cognitive function at follow-up measurement among breast cancer survivors 4. The difference in risk of dementia between breast cancer survivors and cancer-free individuals. 5. The difference in change of inflammatory markers between breast cancer survivors and cancer-free individuals. 6. The relation between cognitive function and inflammatory markers in breast cancer survivors and cancer-free individuals.	—

Measure

Time frame

1. The difference in change of subjective memory complaints between breast cancer survivors and cancer-free individuals 2. The predictive value of cognitive function at the first assessment for cognitive function at follow-up measurement among breast cancer survivors 3. The predictive value of subjective memory complaints at the first assessment predict cognitive function at follow-up measurement among breast cancer survivors 4. The difference in risk of dementia between breast cancer survivors and cancer-free individuals. 5. The difference in change of inflammatory markers between breast cancer survivors and cancer-free individuals. 6. The relation between cognitive function and inflammatory markers in breast cancer survivors and cancer-free individuals.

—

Countries

Netherlands

Outcome results