Lynch syndrome polyps
Conditions
Interventions
Linked Color Imaging (LCI)
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of Lynch-syndrome, with a germline mutation in one of the MMR genes (MLH1, MSH2, MSH6, PMS2) - Surveillance colonoscopy for Lynch syndrome. - Age >18 years
Exclusion criteria
Exclusion criteria: - Recent surveillance colonoscopy within 1 year from current exam (e.g. after piecemeal EMR) or patients referred for endoscopic evaluation of known colorectal neoplasia. - Colonoscopy planned for the evaluation of symptoms like rectal blood loss, recent change in bowel habits, weight loss or anemia. - Patients with a concurrent diagnosis of (serrated) polyposis syndrome or inflammatory bowel disease. - Patients who are unwilling or unable to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is the polyp detection rate of HD-WLE and LCI. Polyp detection rates are defined as the number of patients with at least 1 polyp detected during the inspection divided by the total number of patients included in the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| - The difference in mean number of polyps between HD-WLE and LCI - The difference in adenoma detection rate between HD-WLE and LCI - The difference in mean number of adenomas between HD-WLE and LCI - The difference in mean number of serrated polyps between HD-WLE and LCI - The mean duration of both endoscopic procedures LCI vs. HD-WLE: time for inspection and time for performing endoscopic resection - The sensitivity, specificity and accuracy of optical diagnosis on a per polyp basis | — |
Countries
Netherlands
Outcome results
None listed