Ciprofloxacin pharmacokinetics after IV and oral administration in cachectic elderly patients

Ciprofloxacin pharmacokinetics after IV and oral administration in cachectic elderly patients - CIPCEP

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50150

Enrollment

Registered

2020-06-18

Start date

2020-11-30

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cystitis Pneumonia Urinary tract infection

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Treated witch ciprofloxacin as a part of routine clinical care - >75 years of age - At least one of the following: o BMI 10% of total body weight in the previous 12 months o weight

Exclusion criteria

Exclusion criteria: - Subjects may not be critically ill, i.e. not be admitted to the ICU

Design outcomes

Primary

Measure	Time frame
A farmacokinetic model using Non Linear Mixed Effects Modelling (NONMEM). Model validation using bootstrap method or Sampling lmportance Resampling (SlR). The final modelwill be used for Monte Carlo simulation for multipledosing regimens and higher dosages.	—

Countries

Netherlands

Outcome results