no condition NA
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Must be a member of the Santo Daime church, who volunteers to participate in the research project. * Must be older than 18 years of age.
Exclusion criteria
Exclusion criteria: * Medical devices and implants containing metal (e.g. pacemakers, copper birth control spirals, permanent jewelry, aneurysm clips, hearing aids) * Permanent make-up and other large tattoos * Pregnancy or lactation. * Use of (medicinal) substances in the past 24 hours which can interact with MAO inhibitors, including further MAO inhibitors (tranylcypromine, Parnate, Nardil, Aurorix, etc), all sympathomimetics (including amphetamine, cocaine, methylphenidate, ephedrine, metaraminol, certain asthma agents), certain medicines for cough, cold, hay fever, and allergies that are available without a prescription, such as Otrivin and dextromethorphan-containing agents (Dampo, VapoTab *Vicks*, Darolan and others) and antihistamines, diet medication (such as Ponderal), all antidepressants including SSRIs (citalopram, sertraline, etc) and trycyclic antidepresssents (clomipramine, etc), certain anti-asthma medications such as Berotec, Bricanyl, Ventolin, Salbutamol, Terbutaline, Pulmadil, or Serevent, blood pressure medication (beta blockers, methyldopa, thiazide diuretics, calcium antagonists, and ace inhibitors), antimicrobials or antibiotics, narcotic analgesices (including pethidine), or other substances like St. John*s wort, lithium, alprazolam, buspirone, L-tryptophan, L-DOPA, disulfiram, hydralazine (such as Apresoline), and carbamazepine (such as Tegretol). * Use of Prozac in the past 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the drug induced change in brain activity and neurometabolite concentration when comparing ayahuasca to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additionally, the change in subjective state and cognitive flexibility will be assessed and correlated with the neurological effects. Lastly, we will evaluate the modulatory effects of the ceremonial setting on these changes through a controlled music paradigm. | — |
Countries
Netherlands
Outcome results
None listed