Improving enteral drug delivery with low molecular weight alginate oligosaccharides

Improving enteral drug delivery with low molecular weight alginate oligosaccharides - Alginate Drug Delivery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50130

Enrollment

Registered

2020-08-12

Start date

2020-10-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

secretory diarrhea

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Aged 18-55. Enrollment by informed written consent

Exclusion criteria

Exclusion criteria: Coagulation disorders Use of anticoagulants. (Chronic) constipation. (As this may indicate aberrant intestinal ion and fluid transport.)

Design outcomes

Primary

Measure	Time frame
IC50 values of test compounds for inhibition of the ICM response of rectal biopsies.	—

Secondary

Measure	Time frame
IC50 values of test compounds for inhibition of the ICM response in intestinal cell cultures (organoids). Histology of biopsies. Gene expression.	—

Countries

Netherlands

Outcome results