DPP3 levels in out of hospital cardiac arrest patients admitted to the intensive care unit: an explorative study

DPP3 levels in out of hospital cardiac arrest patients admitted to the intensive care unit: an explorative study - DPP3inOHCA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50128

Enrollment

Registered

2020-06-17

Start date

2020-11-10

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

'cardiac arrest' 'heart-attack' 'out of hospital cardiac arrest'

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Out of hospital cardiac arrest - Intensive Care admission (this applies to all out-of-hospital cardiac arrest patients who required endotracheal intubation because they did not regain consciousness within 20 minutes of onset of cardiac arrest)

Exclusion criteria

Exclusion criteria: - Necessity for extracorporeal membrane oxygenation, intra-aortic balloon pumps - Patients admitted with an already proposed withdrawal of life-sustaining treatment because of diagnosed irreversible neurological injury or because of treatment limitations expressed by the patient before the event.

Design outcomes

Primary

Measure	Time frame
Plasma DPP3 levels and DPP3 enzyme activity. Correlation with development of post-cardiac arrest syndrome, 28 day mortality.	—

Secondary

Measure	Time frame
Development of vasodilatory shock with concurrent vasopressor dosage necessity, plasma cytokine concentrations, development of other complications related to disease/treatment, vital parameters, kidney function, blood gas values, age, body mass index, cause of cardiac arrest, sequential organ failure assessment (SOFA) score, use of medication, survival	—

Countries

Netherlands

Outcome results