cognitieve prestatie cognitive performance (performance monitoring)
Conditions
Interventions
Oxytocin, L-DOPA, or placebo will be administered in randomized order over the
course of three sessions. After administration, resting state and structural
scans will be made and participants will p
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy, right-handed males between age 18 and 35 with no history of neurological disorder/disease, no substantial psychiatric history, and no counter-indications to MRI will be included in this study.
Exclusion criteria
Exclusion criteria: Participants should meet none of the following exclusion criteria: - History of medication or drugs within 1 month prior to the start of treatment with trial medication with the exception of occasional use of paracetamol. - Previous experience of allergic reaction upon administration of a drug. - Use of hayfever medication - Medical or surgical history that in the investigator*s view may significantly affect the outcome of the trial; such as severe visual impairment - Significant history of head trauma, premature birth, or learning disabilities. - Heart arrhythmia (including pacemaker/ICD), glaucoma, hypertension. - Clinically significant history of abnormal cardiovascular, endocrine, psychiatric, neurological or hematological disease. - Febrile illness within 3 days before the first dose - Fever or cold within 2 days before the experiment - Participation in another drug study within 3 months preceding participation in the current study. - Intake of more than 3 units of alcohol / day - Smoking more than 5 cigarettes / day - Inability to understand the nature and extent of the trial and the procedures required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain activation during the various tasks and scans (resting state scans, Cannonball task, Prosocial Probabilistic Learning task, Working Memory task) across the different (pharmacological) conditions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioural outcomes such as accuracy and self-reported responsibility levels in the different tasks and scans (resting state scans, Cannonball task, Prosocial Probabilistic Learning task, Working Memory task) across the different (pharmacological) conditions. | — |
Countries
Netherlands
Outcome results
None listed