acute traumatic coagulopathy Trauma-induced coagulopathy
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy male volunteers (age: 18-35 years)
Exclusion criteria
Exclusion criteria: - Participation in a scientific intervention study in the last 3 months - No informed consent - History of coagulation disorders - Active use of prescription medication - Use of anticoagulant medication, including aspirin - History of liver disease - History of chronic transmittable disease - History of alcohol, smoking or drug abuse - History of alcohol/drug use in past 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In vitro: whether open conformation of ADAMTS13 is associated with hyperfibrino(geno)lysis determined by ROTEM, coagulation proteins measurements, and/or other whole blood or plasmatic coagulation tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be related to factors contributing to open conformation ADAMTS13 and the effects of ADAMTS13 and/or hyperfibrino(geno)lysis on coagulation components such as platelets. | — |
Countries
Netherlands
Outcome results
None listed