The role of left atrial fibrosis in mitral valve repair surgery

The role of left atrial fibrosis in mitral valve repair surgery - The role of LA fibrosis in MVP surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50111

Enrollment

Registered

2021-12-14

Start date

2022-02-04

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mitral valve insufficiency mitral valve regurgitation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Mitral valve insufficiency patients who meet the criteria for mitral valve repair surgery and are on the waiting list for elective surgery.

Exclusion criteria

Exclusion criteria: Atrial fibrillation, History of cardiac surgery Comorbidities MRI contra-indications (see protocol for specification)

Design outcomes

Primary

Measure	Time frame
The main study parameters are: 1. Severity of MVI prior to and after surgery (defined as regurgitation volume in ml) 2. Left atrial remodelling prior to and after surgery 3. Presence and distribution patterns of LA fibrosis 4. Blood flow patterns in the left atrium (4D flow)	—

Secondary

Measure	Time frame
Secondary study parameters are: -Biomarkers derived from blood samples (NT-proBNP, TNF-β, Angiotensin II, cytokines) -Heart failure symptoms monitoring derived from questionnaire preoperative and at postoperative follow-up	—

Countries

Netherlands

Outcome results