Inspiratory Muscle Training in Myotonic Dystrophy type 1: a pilot study.

Inspiratory Muscle Training in Myotonic Dystrophy type 1: a pilot study. - IMT study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50107

Enrollment

Registered

2020-04-07

Start date

2021-03-10

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myotonic Dystrophy type 1

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Diagnosed with DM1 (based on DNA features). - Age >= 18 years old. - Reduced PImax and vital capacity (both

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Need or indication for HMV (daytime hypercapnia, pCO2 >= 6.0 kPa) - Inability to adequately use a POWERbreathe, for example air leak during maneuvers. - Inability to communicate or answer questionnaires. - Vital capacity

Design outcomes

Primary

Measure	Time frame
Difference in inspiratory muscle strength and endurance capacity after 12 weeks IMT program compared with baseline.	—

Secondary

Measure	Time frame
Additional effects of IMT will be investigated on symptoms (using questionnaires about cough, dyspnea, fatigue, quality of life), longvolumes using spirometry, gas-exchange during the night. Also effects on the diaphragm will be measured using ultrasound and EMG.	—

Countries

Netherlands

Outcome results