A new approach to determine the age of (sub)acute and chronic subdural hematomas

A new approach to determine the age of (sub)acute and chronic subdural hematomas - OCCULT study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50105

Enrollment

Registered

2020-12-22

Start date

2021-02-09

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bleeding in the subdural space Subdural hematoma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * 18 years or older; * the patients, or their legal representative, have signed an informed consent; * have a traumatic acute, subacute or chronic subdural hematoma; * the date of trauma must be known or when the expected trauma occurred more than 14 days ago and the patient is not sure of the date, an approximate estimate of the date.

Exclusion criteria

Exclusion criteria: * recurrent subdural hematoma; * previous surgery for subdural hematoma in the past 365 days; * inability to obtain informed consent from the patient (or when the patient has a depressed level of consciousness their legal representative), including language barrier.

Design outcomes

Primary

Measure	Time frame
The main study parameters are the concentrations over time of six biomarkers (UCHL1, ICAM5, NFH, MBP, GFAP and NGF) in subdural blood. GFAP Glial fibrillary acidic protein ICAM-5 Intercellular adhesion molecule 5 MBP Myelin basic protein NFH Neurofilament heavy chain NGF Nerve growth factor UHCL1 Ubiquitin C-terminal hydrolase L1	—

Secondary

Measure	Time frame
The second study parameters are hemoglobin derivatives (HbO2, met-Hb, HC, Biliverdin and Bilirubin) in subdural blood. Hb Hemoglobin HbO2 Oxyhemoglobin HC Hemichrome	—

Countries

Netherlands

Outcome results