Not applicable
Conditions
Interventions
Participants will receive either propranolol hydrochloride (40 mg oral
administration
a safe challenge that temporarily blocks * -adrenergic
receptors) or metyrapone (metopirone©, 750 mg orally administered twice, a safe
challenge that temporarily blocks cortisol synthesis) and will
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Written informed consent * Good physical and mental health as determined by medical screening * Age between 18 and 35 * BMI between 17.5 - 28 * Females: use of hormonal contraceptives * Native language: Dutch, German or English * A competent level of English to answer the questionnaires * Willing to eat yoghurt on test day 3
Exclusion criteria
Exclusion criteria: * Diagnosis of a psychiatric disorder (DSM-V) * Use of any pharmacological treatment at time of inclusion * Current recreational drug use/dependence * Current alcohol dependence * Pregnancy or plans to get pregnant in the near future; * Contraindications to metyrapone or propranolol o Propranolol: * - Diagnosis of a neurological or cardiac disease * - Obstructive respiratory disease * - Hypotension (diastolic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the extent of intentional forgetting in the Imagine/No-Imagine task and the underlying neural correlates assessed with electroencephalography (EEG). | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional dependent variables are the neuroendocrine stress markers (cortisol and salivary *-amylase (sAA)) and measures of cognitive functioning (i.e., working memory, inhibition). | — |
Countries
Netherlands
Outcome results
None listed