Labelled-butyrate and labelled-glucose breath testing to detect mesenteric ischemia, a proof of principle study in healthy volunteers

Labelled-butyrate and labelled-glucose breath testing to detect mesenteric ischemia, a proof of principle study in healthy volunteers - CMI breath test

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON50079

Enrollment

Registered

2020-04-29

Start date

2020-04-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic mesenteric ischemia intestinal oxygen shortage

Interventions

Three control groups consisting of 5 volunteers will be used during the study. The first group will receive an oral dose of 0.03 µmol 13C-butyrate, the second group 3.5 gr D-glucose-1-13C, and the t

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * *18 years of age * Experience with cycling * Signed informed consent * Unremarkable medical history (no gastrointestinal diseases, no cardiac or pulmonary diseases) * No gastrointestinal complaints

Exclusion criteria

Exclusion criteria: * Unable to sign informed consent * Pregnancy

Design outcomes

Primary

Measure	Time frame
The possibility of detecting mesenteric ischemia by 13C-butyrate, 13C-glucose, and 13C-glucose and D-butyrate breath testing by differences in timing and concentration of the peak of expired 13CO2 and DHO between control and intervention group.	—

Secondary

Measure	Time frame
To determine the optimal oral dose of D-butyrate for the measurement of D-butyrate metabolism in enterocytes by performing a DHO breath test	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)