Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In Tanzania/Brazil, I will include 75 patients with idiopathic Parkinson*s disease who have not been treated with any form of dopaminergic medication (including Mucuna pruriens, which is a tropical legume native to Africa, rich of levodopa). In the Netherlands, I will include 75 patients who have received levodopa-treatment (patients will be matched for disease duration, age and gender). In both cohorts, patients should have a disease duration of at least 5 years, because freezing is rare for patients with a shorter disease duration.
Exclusion criteria
Exclusion criteria: Exclusion criteria include significant co-morbidity limiting the interpretation of ambulation and inability to walk unaided.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence and severity of freezing of gait will be assessed subjectively using the New-Freezing of gait Questionnaire. Moreover, the presence of freezing of gait will be objectified using the timed-up-and-go test, and four rapid 360-degrees turns in both directions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Phenotype of freezing of gait. | — |
Countries
Netherlands
Outcome results
None listed