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Sex hormones, cognition, and the role of cardiovascular and psychological factors: a study in elderly transgender women and men receiving long-term gender-affirming hormone therapy in comparison with cis men and women from the LASA cohort.

Sex hormones, cognition, and the role of cardiovascular and psychological factors: a study in elderly transgender women and men receiving long-term gender-affirming hormone therapy in comparison with cis men and women from the LASA cohort. - Cognition in elderly transgender individuals

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON50025
Enrollment
120
Registered
2020-03-12
Start date
2021-05-10
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patienten met genderdysforie gender dysphoria gender incongruence

Interventions

None listed

Sponsors

Vrije Universiteit Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >55 years Diagnosis of gender dysphoria Continued and consistent use of GHT for at least 10 years Currently in treatment at the Center of Expertise on Gender Dysphoria (i.e., last clinical appointment

Exclusion criteria

Exclusion criteria: No sufficient understanding of the Dutch language Subjects that indicate on forehand to be too frail for full participation in the study

Design outcomes

Primary

MeasureTime frame
Endpoints that are of particular interest to this study and have been studied within the LASA framework include: general cognitive functioning (Mini-Mental State Examination), coding task, 15-word test (immediate and delayed recall), letter and category fluency, GIT, and number series (forward and backward). An exhaustive list of items that are part of the general LASA data collection can be found in Huisman et al (2011), and Hoogendijk et al. (2016), attached.

Secondary

MeasureTime frame
The following variables will be investigated as mediators: 1) psychological factors including depressive symptoms (CES-D) and anxiety (HADS-A), self-esteem/efficacy questionnaire, life satisfaction and (history of) psychiatric/psychological help, and 2) social factors including loneliness (De Jong-Gierveld & Kamphuis Loneliness Scale) and discrimination, and 3) cardiovascular parameters including self-report on cardiovascular disease, diabetes, stroke and high blood pressure, medication use, health-related behaviour (smoking, alcohol consumption, sleep), BMI and blood pressure (2x). In addition, the following demographic information will be gathered: sex/gender, age, region in the Netherlands, marital status, housing, spirituality, socioeconomic status, feelings of masculinity/femininity. Information regarding contentment with medical treatment(s), body satisfaction, and sexuality will be collected as well.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)