depression
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age: 18+ years old • Chronic or recurrent major depressive disorder (MDD) diagnosis , both with current episode or in remission • Able to give informed consent
Exclusion criteria
Exclusion criteria: • Impossibility to obtain a valid informed consent • Insufficient comprehension of the Dutch language • Physical, cognitive, or intellectual impairments interfering with participation, such as deafness, blindness, or sensorimotor handicaps • Formerly/currently involved in MBCT or MBSR training • Meets criteria for bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective illness or anorexia nervosa. • Current psychosis • High level of suicidality • Drug or alcohol addiction in the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary objective is to understand the role of rumination in depressive symptoms changes in chronic and recurrent MDD patients as a result of MBCT treatment. Therefore we will assess rumination and depressive symptoms repeatedly during MBCT and will investigate the effect of MBCT on a novel, on-line behavioural task of rumination, namely the Breathing Focus Task (BFT). We will also use questionnaires to assess rumination and depressive symptoms. | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary aim is to elucidate the cognitive mechanisms concerning negative inhibitory processing in working memory and behaviour that possibly underlie depression and rumination and the effect of MBCT. For this, we will look at aversive PIT and evaluate its relation with depression. We will also test emotion specific working memory function and evaluate its relation with rumination. Additionally, the effect of MBCT on these parameters will be assessed. For this we will use the Pavlovian-Instrumental Transfer (PIT) task and the Working Memory Update/Ignore Emotion Task (WMUIET), together with questionnaires and the BFT task to assess rumination. | — |
Countries
Netherlands
Outcome results
None listed