Diabetes Mellitus
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18 years and older Non insulin dependent DM No medical disease Vital signs within specific boundries Healthy apart from their DM \See page 13 of the protocol
Exclusion criteria
Exclusion criteria: * Insulin dependent diabetes mellitus * Diagnosed Obstructive Sleep Apnea (OSAS) or high suspicion of OSAS determined by a STOP-BANG score > 5 * Respiratory or cardiovascular disease * Smoking/vaping * Positive pregnancy test * conditions that result in elevated levels of methaemoglobinia * body mass index > 35 kg/m2 * Use of illicit drugs * Use of prescription opioids or benzodiazepines * Failure of the drug of abuse tests at screening or check-in. * History of dyspnea, asthma, tuberculosis, chronic obstructive pulmonary disease, or any other ventilatory / lung disease. * Subjects with excessive facial hair preventing sealing of the occlusive face mask. * Subjects who, in the opinion of the investigator, will not be able to participate optimally in the study. * Subject who has a history of any infectious disease within 4 weeks prior to drug administration that in the opinion of the investigator, affects the subject*s ability to participate in the trial. * Subjects who are part of the study staff personnel or family members of the study staff personnel. * Subjects who have demonstrated allergic reactions (e.g., food, drug, atopic reactions or asthmatic episodes) which, in the opinion of the investigator and sponsor, interfere with their ability to participate in the trial. * Personal or family history of arrhythmias or ECG conductance abnormalities. * Hypokalemia defined as
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxic ventilatory response | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability | — |
Countries
Netherlands
Outcome results
None listed