Eiwitmetabolisme in verschillende musckuloskeletale weefsels Hip fracture proximal femoral fracture
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Written informed consent; 2) Recent (
Exclusion criteria
Exclusion criteria: 1) Physical restlessness due to delirium; 2) Rheumatoid arthritis; 3) Chemotherapy or radiotherapy; 4) (Multiple) Myeloma or other primary cancer tumor with possible bone metastasis; 5) Collagen disorders, e.g. Marfan and Ehler-Danlos; 6) Any other medical condition that may interfere with the safety of the subjects or the outcome parameters, in the investigators judgement; 7) Investigator*s uncertainty about the willingness or ability of the subject to comply with the protocol instructions; 8) Participation in any other studies involving investigational or marketed products concomitantly to entry into the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameters are bone protein synthesis rates in the femoral shaft and femoral head tissue, expressed in FSR (%/h). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters are tissue-specific protein synthesis rates in femoral bone, femoral head cartilage, hip synovium, and skeletal muscle, expressed in FSR (%/h). In addition, plasma enrichments of L-[ring-13C6]-phenylalanine is a secondary outcome parameter. | — |
Countries
Netherlands
Outcome results
None listed