COVID-19 pneumonia
Conditions
Interventions
Ultra-low dose radiotherapy treatment of 0.5 Gy to both lungs.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * PCR confirmed positive for SARS-CoV-2 * Progressive respiratory insufficiency with the following: o National Early Warning Score (NEWS) * 5. o Respiratory rate * 20/min o Supplemental oxygen * 6L/min * DNR (Do not resuscitate, *NRNB*). * Clinical frailty scale 5-8 at admission. * Age * 50 years. * Ability of subject to understand character and individual consequences of the clinical trial.
Exclusion criteria
Exclusion criteria: * Medical indication to be treated at the ICU (intensive care unit). * Current participation in other intervention studies. * Prior thoracic radiotherapy only if * grade 3 toxicity has been registered. * Inability to undergo radiotherapy or transportation, for any reason as determined by the treating physician. * Alternative diagnosis for respirator insufficiency which is considered to be more likely than COVID-19. * Current treatment with immunomodulating therapy other than steroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint will be supplemental oxygen use; 1, 3 and 5 days after treatment, and at discharge (or after 21 days). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will be survival, vital parameters, pro-inflammatory parameters in the blood, and lesion changes on imaging. | — |
Countries
Netherlands
Outcome results
None listed