Mucosal immunity in patients diagnosed with SARS-CoV-2 infection and their household contacts

Mucosal immunity in patients diagnosed with SARS-CoV-2 infection and their household contacts - Mucosal immunity against coronavirus infection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49964

Enrollment

200

Registered

2020-03-18

Start date

2020-03-26

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronavirus COVID-19

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patient with a laboratory-confirmed SARS-CoV-2 infection in home isolation with at least two household contacts remaining in home quarantine at the same address.

Exclusion criteria

Exclusion criteria: Patients with a negative indication for home isolation

Design outcomes

Primary

Measure	Time frame
This is an exploratory study in which the primary aim is to study the development of antibodies to SARS-CoV-2 in nasal fluid of COVID-19 patients and their household contacts. Primary outcome: - Descriptive analysis of SARS-CoV-2 IgG and IgGA concentrations in nasal fluid at the various time points.	—

Secondary

Measure	Time frame
- Detection of SARS-CoV-2 in diagnostic specimen - Descriptive analysis of inflammatory markers in nasal fluid - Descriptive analysis of correlation of antibodies with viral diagnostics and disease symptoms	—

Countries

Netherlands

Outcome results