Transdiagnostic processes in (comorbid) anxiety disorder(s), post-traumatic stress disorder, obsessive-compulsive disorder and depression (TAPOD)

Transdiagnostic processes in (comorbid) anxiety disorder(s), post-traumatic stress disorder, obsessive-compulsive disorder and depression (TAPOD) - TAPOD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49963

Enrollment

574

Registered

2021-05-18

Start date

2021-12-28

Completion date

Unknown

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

affective disorders stress-related disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Current (primary) Axis I diagnosis of anxiety (GAD, Social Phobia, Panic Disorder, Agoraphobia), PTSD or OCD and/or depression (MDD, Persistent Depressive Disorder) diagnosis (assessed using the Mini-international Neuropsychiatric Interview) From age 18 onwards Fluent in Dutch Able to give Informed Consent

Exclusion criteria

Exclusion criteria: Insufficient comprehension of the Dutch language Physical, cognitive, or intellectual impairments interfering with participation, such as deafness, blindness, or sensorimotor handicaps Diagnosis of bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective illness Current psychosis Drug or alcohol addiction in the past 6 months

Design outcomes

Primary

Measure	Time frame
The main study parameters at all timepoints across all groups are: the severity of anxiety and depressive symptoms (assessed with the BAI and IDS-SR), RNT and avoidance (assessed with the RRS, PSWQ, MRNT; BFT, CBAS, BEAQ and Manikin task), cognitive control (assessed with the ATQ-short and IST).	—

Secondary

Measure	Time frame
The secondary study outcome differ per group, see below. Across all patient groups: Intolerance of uncertainty, perceived criticism and general clinical outcomes (assessed with the IUS, PC and OQ, respectively). Anxiety group only: Autobiographical specificity and selectivity (assessed with the AMT and AMT-F in anxiety disorders and stress-related disorders), autobiographical memory function (assessed with the TALE), problem-solving ability (assessed with the MEPS), disorder specific symptom measures for SAD (assessed with the LSAS), panic disorder (assessed with the PDSS-SR) and agoraphobia (assessed with the Mobility Inventory). Depression group only: Anhedonia (assessed with the DARS-NL and SHAPS-NL), autobiographical specificity and selectivity (assessed with the SRET in depressive disorders), physical activity (as clinical outcome; assessed with the IPAQ). PTSD and OCD groups only: Autobiographical specificity and selectivity (assessed with the AMT and AMT-F), autobiographical memory function (assessed with the TALE), problem-solving ability (assessed with the MEPS), disorder specific symptom measures for PTSD and OCD (assessed with the PSS-SR and Y-BOCS respectively).	—

Measure

Time frame

The secondary study outcome differ per group, see below. Across all patient groups: Intolerance of uncertainty, perceived criticism and general clinical outcomes (assessed with the IUS, PC and OQ, respectively). Anxiety group only: Autobiographical specificity and selectivity (assessed with the AMT and AMT-F in anxiety disorders and stress-related disorders), autobiographical memory function (assessed with the TALE), problem-solving ability (assessed with the MEPS), disorder specific symptom measures for SAD (assessed with the LSAS), panic disorder (assessed with the PDSS-SR) and agoraphobia (assessed with the Mobility Inventory). Depression group only: Anhedonia (assessed with the DARS-NL and SHAPS-NL), autobiographical specificity and selectivity (assessed with the SRET in depressive disorders), physical activity (as clinical outcome; assessed with the IPAQ). PTSD and OCD groups only: Autobiographical specificity and selectivity (assessed with the AMT and AMT-F), autobiographical memory function (assessed with the TALE), problem-solving ability (assessed with the MEPS), disorder specific symptom measures for PTSD and OCD (assessed with the PSS-SR and Y-BOCS respectively).

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Countries

Netherlands

Outcome results