hypokinetic rigid syndrome Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Willingness to cooperate and sign written informed consent Patients: - Clinical diagnosis of idiopathic Parkinson*s disease by a neurologist.
Exclusion criteria
Exclusion criteria: - Incapable to provide informed consent - Treatment with anticholinergics - Current or recent treatment with ChEIs - Presence of deep brain stimulation implants - (Suspected) pregnancy - Migraine - Epilepsy - Participation in a scientific research study during the past year involving radiation - MRI contra-indications, e.g. o Ferrous objects in or around the body (e.g. braces, pacemaker, metal fragments) o Claustrophobia - Insufficient knowledge of the Dutch language Control subjects: - History of neurological or neurodegenerative disorder Parkinson Disease Dementia: - Unsafe or irresponsible to postpone treatment with cholinesterase inhibitor, according to treatment provider
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter resulting from the SAI-measurement is percentage of conditioned motor evoked potential (MEP) versus unconditioned MEP. The main study parameter resulting from [18F]FEOBV PET imaging is the mean cortical tracer binding. We will perform a correlation analysis between these parameters as a main outcome measure. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Tracer binding in different ROIs and per voxel. - Outcome of all questionnaires and clinical tests as mentioned under E4. - Resting-state functional connectivity. | — |
Countries
Netherlands
Outcome results
None listed