The role of the gut microbiome in the pathogenesis of IgA nephropathy

The role of the gut microbiome in the pathogenesis of IgA nephropathy - The role of the gut microbiome in the pathogenesis of IgA nephropathy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49937

Enrollment

150

Registered

2021-09-28

Start date

2021-10-27

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glomerulonephritis IgA nephropathy

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Biopsy-proven eGFR 15 - 90 ml/min/1.73m2 Age 18 - 70 years

Exclusion criteria

Exclusion criteria: No informed consent Secondary causes of glomerular IgA depositions: - Liver disease; cirrhosis, hepatitis B - Gastro-intestinal disease; inflammatory bowel disease (IBD), celiac disease, major gastro-intestinal surgery - Skin disease; dermatitis herpetiformis, psoriasis - Pulmonary disease - Malignant disease - Current infection - IgA monoclonal gammopathy - The use of immunosuppressive drugs - Antibiotic treatment

Design outcomes

Primary

Measure	Time frame
Does the gastro-intestinal bacterial ecosystem between patients with IgA nephropathy differ from control renal patients and healthy controls? If so, in what way?	—

Secondary

Measure	Time frame
1. Can disruption of the gastrointestinal bacterial ecosystem be linked to disease severity? 2. Are there associations between health traits/dietary habits and the gastrointestinal bacterial ecosystem?	—

Countries

Netherlands

Outcome results