Physical activity for people with Parkinson's disease and Multiple Sclerosis: effect on body and mind

Physical activity for people with Parkinson's disease and Multiple Sclerosis: effect on body and mind - HersenFIT

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON49908

Enrollment

Registered

2022-02-22

Start date

2022-06-16

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

The intervention period lasts 8 weeks, consisting of 1. high-intensity interval training: 2x/week, workload alternates (45 sec at >85% of Wmax

90 sec at 20-30% of Wmax) during a 30-minute session (cycle ergometer)

2. continuous aerobic training: preset workload of 55% of Wmax during 50-minute session (cycle ergometer)

3. movement advice: program with pedometer and weekly step goals, and information about the added value of being physically active (from home).

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. diagnosis of Parkinson's disease (PD) or Multiple Sclerosis (MS); 2. Hoehn & Yahr stage =8 on anxiety and/or depression subscale]; 4. able to participate in physical exercise program (i.e., no history of heart programs, no symptms that might indicate heart problems (e.g., disturbed resting ECG), no other major health issues); 5. sufficient cognitive ability to comprehend training instructions [MoCA score >21]; 6. stable medication regime for at least four weeks; and 7. age >=18 years

Exclusion criteria

Exclusion criteria: 1. participation in physical exercise program

Design outcomes

Primary

Measure	Time frame
Anxiety and depression (HADS)	—

Secondary

Measure	Time frame
Disease severity (UPDRS, EDSS) Cognition (Stroop, TMT, SDMT) Fatigue (CIS-20r) Sleep quality (ISI) Well-being/disease impact (PDQ-8, MSIS) Quality of life (SF-36) Fysieke prestatie (10MWT, TUG, NHPT) ADL (NEADI) Fysieke activiteit (PASIPD) Hersennetwerk connectiviteit (MRI)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)