disorder of muscle tension Dystonia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to participate in this study, CD patients must meet the following criteria: • Patients with a clinically confirmed diagnosis of idiopathic CD and age >= 18 years; • A life expectancy of at least one year after surgery; • For the patients in the EMG-part: DBS indication approved by the DBS team of the patients hospital. The inclusion criteria for the controls are: • Age- and gender match to the participating patients; • Life expectancy of at least one year after inclusion in the study; • Age >= 18 years.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study. CD patients and controls: • Relevant neurological conditions other than CD; • Previous brain surgery; • Impossibility to stop anticholinergic medication; • Pregnancy or breast feeding; • Exhibition to a radiation dose for medical research, exceeding the maximum annual dose; • Contra-indication for MRI scanning (MR incompatible implants, risk of metal particles in the eyes, tattoos containing red pigments, sensitivity to contrast fluid); • Claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are: - The difference in [18F]FEOBV PET binding between CD patients and controls, and its relation to motor- and NMS. - The difference in intermuscular coherence between CD patients and controls, and its relation to motor- and NMS. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint of this study is the intermuscular coherence (pre- and post-DBS) and cholinergic binding (only pre-DBS), and whether pre-operative measurements are predictive for the effect of DBS on motor- and NMS. | — |
Countries
Netherlands
Outcome results
None listed