posttraumatic stress disorder | trauma
Conditions
Interventions
A single reactivation session of trauma memory followed by the administration
of 40 mg of the noradrenergic &beta
-blocker propranolol.
Sponsors
TNO
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. aged between 18 and 65 years; 2. a primary diagnosis of PTSD according to DSM-V 3. a score of > 20 on the Post-traumatic Symptom Scale at screening
Exclusion criteria
Exclusion criteria: 1. other relevant treatment for PTSD within 3 months before start of the study 2. start of new medication within 3 months before start of study 3. life-time psychosis 4. acute suicide risk 5. current state of asthma or COPD, which necessitates medication use 6. cardiovascular diseases or irregular heartbeat 7. hypotension or hypertension 8. pregnancy or breastfeeding 9. epilepsy 10. any medication contra-indicative of the use of propranolol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary output will be (a) the percent change in PTSD diagnosis and (b) the decrease in frequency and severity of PTSD symptoms, from baseline to post-treatment and follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed