Broken hip, Hip fracture Hip fracture
Conditions
Interventions
There will be two groups, an intervention group receiving a tailor-made
protein-enriched diet and an extended exercise training program, and a control
group receiving usual care.
Sponsors
Wageningen Universiteit
Eligibility
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age >= 65 years * Acute hip fracture * Able to give written informed consent * Mentally competent, as judged by the treating physician * Admission to a rehabilitation centre that participates in this research
Exclusion criteria
Exclusion criteria: * Allergic, intolerant or hypersensitive to milk/lactose (self-reported) * Not willing to stop using dietary supplements with the exception of calcium and vitamin D, or supplements prescribed by a physician. * Pathological fracture or periprosthetic fracture * Abnormal hepatic or renal laboratory parameters, such as estimated glomerular filtration rate (eGFR) <30 ml/min/1,73 m2 (data from hospital) * Diagnosis of disorders/diseases where a high protein intake can be harmful, such as renal impairment or failure, or liver disease (elderly care physician has the decisive voice). * Diagnosis of bone metabolic disorders such as primary hyperparathyroidism, Paget*s disease, or myeloma * Taking medication other than bisphosphonates known to strongly alter bone, calcium or muscle metabolism, such as oestrogen, hormone replacement therapy, corticosteroids, anabolic agents or calcitonin. * Disorders/diseases which may affect ability to follow study protocol and which cannot be overcome with help of a caregiver * Current participation in other scientific research * No permission to request information from the general practitioner/ treating specialist(s) about medical history, medication use, liver and kidney values, and details about the broken hip
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Physical performance | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle massBloodmarkers: P1NP, IGF-1, PTHLevels of (free) 25(OH)D, folate, vitamin B12, and vitamin CBone mineral density: total hip, femoral neck, and total bodyQuality of lifeInpatient rehabilitation timeDaily life functioningFear of falling | — |
Countries
Netherlands
Contacts
Public ContactI Groenendijk
Wageningen Universiteit
Outcome results
None listed