Podocytes derived from induced pluripotent stem cells as biomarker of disease-causing mutations

Podocytes derived from induced pluripotent stem cells as biomarker of disease-causing mutations - Podocytes from stem cells mimick disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49859

Enrollment

Registered

2019-08-19

Start date

2019-10-28

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

collagen type IV nephropathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Patients * Established diagnosis of collagen IV nephropathy with disease-causing Col4 mutation. 2. Disease controls: * diagnosis of focal segmental glomerulosclerosis (FSGS) with no evidence of underlying genetic mutations. 3. Healthy controls: * no signs of kidney disease, negative family history of kidney diseases (i.e. proteinuria or hematuria with no proven cause).

Exclusion criteria

Exclusion criteria: * Unspecified kidney injury; * Not able to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Abnormal function of podocytes from patients with proven disease causing mutations compared to disease and healthy controls.	—

Countries

Netherlands

Outcome results