T-cell activation in high lipoprotein(a) patients

T-cell activation in high lipoprotein(a) patients - T-cell activation in high lipoprotein(a) patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49849

Enrollment

100

Registered

2020-07-01

Start date

2020-09-10

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis cardiovascular disease high lipoprotein(a)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. High lipoprotein(a) with known cardiovascular disease 2. Low lipoprotein(a) with known cardiovascular disease 3. High lipoprotein(a) without known cardiovascular disease 4. Low lipoprotein(a) without known cardiovascular disease

Exclusion criteria

Exclusion criteria: - HIV - Chronic kidney disease - Any condition which could possibly interfere with the conduction or outcome of the study to the opinion of the investigator

Design outcomes

Primary

Measure	Time frame
We will compare the phenotype, cytokine production and epigenetic characteristics of T cells between patients with high and low Lp(a), with and without a history of cardiovascular disease. Additionally, we will determine the conditions under which healthy T cells are promoted to pro-inflammatory phenotypes and evaluate the ex vivo reversibility of this phenotype.	—

Countries

Netherlands

Outcome results