The association of paternal factors with recurrent pregnancy loss; REMI III study

The association of paternal factors with recurrent pregnancy loss; REMI III study - REMI III study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49845

Enrollment

270

Registered

2019-04-08

Start date

2019-06-12

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

habitual abortion Recurrent miscarriages

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Couples with unexplained recurrent pregnancy loss (defined according to the ESHRE 2017 guideline) who visit the recurrent pregnancy loss clinic in the Leiden University Medical Center (LUMC) or Erasmus Medical Center (EMC) are included.

Exclusion criteria

Exclusion criteria: Exclusion criteria are 1. Known causes for RPL(parental chromosomal abnormalities, uterine anomalies, acquired thrombophilia, thyroid autoimmunity) 2. Mentally or legally incapability 3. Pregnancy after oocyte- embryo or spermatozoa donation 4. Loss of

Design outcomes

Primary

Measure	Time frame
Primary exposure of case control study: paternal age Primary outcome of cohort study: the development of live birth within 5 years after initial visit of the recurrent miscarriage clinic	—

Secondary

Measure	Time frame
Secondary exposures of case control study: BMI, smoking, physical exercise, sperma apoptose, immunomodulatory factors in peripheral blood and seminal plasma (cytokines) Secondary outcomes of cohort study: development of ongoing pregnancy (>24 weeks), time interval until next pregnancy, development of pregnancy complications such as growth restriction, pre term delivery and pre eclampsia	—

Countries

Netherlands

Outcome results