(chronic pain), peripheral sensitization, central sensitization Chronic Pain
Conditions
Interventions
None listed
Sponsors
University of Twente
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 16 and 40 years old.
Exclusion criteria
Exclusion criteria: * Participant refusal during the study. * Language problems. * Skin problems at site of stimulation or EEG recording. * Diabetes. * Implanted stimulation device. * Pregnancy. * Usage of analgesics within 24 hours before the experiment. * Consumption of alcohol or drugs within 24 hours before the experiment. * Pain complaints at the time of the experiment. * A medical history of chronic pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - NDTs Subject Response: The subject*s response to the stimulus, detected or not detected. - EEG Signals: Electric signals reflecting the subject*s neurophysiological activity related to the stimulus, extracted at a fixed interval around every stimulus. - NRS after HFS stimulation: Scoring the intensity of pinpricks by means of numerical rating score after inducing secondary hyperalgesia using high-frequency stimulation. - Punctate mechanical stimulation: Pinprick stimulation using Semmes-Weinstein monofilaments for assessing the occurrence of secondary hyperalgesia | — |
Secondary
| Measure | Time frame |
|---|---|
| - Response Time: Subject*s response time. - Participant Characteristics: Age and sex, handedness. - Electrode-skin Impedance: To assess whether the setup of the HFS was able to reach the required voltages for intensity 20 times higher the subject*s detection threshold. | — |
Countries
Netherlands
Outcome results
None listed