SMA Motor Map - an extensive neurophysiologic protocol to assess (dys)function of the peripheral motor circuits in SMA

SMA Motor Map - an extensive neurophysiologic protocol to assess (dys)function of the peripheral motor circuits in SMA - SMA Motor Map

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49834

Enrollment

177

Registered

2020-04-15

Start date

2020-05-28

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Atrophy Spinal Muscular Atrophy

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Part One: • SMA type 1, 2, 3 and 4, confirmed with a homozygous or heterozygous deletion of SMN1 • *12 years and older • Treatment-naïve concerning SMN- modulators or NMJ-modulators (including pyri-dostigmine and oral salbutamol) o In case of the use of pyridostigmine by indication of SMA, patients are asked to stop treatment 1 day prior to the examination Part Two: • SMA type 1, 2, 3 and 4, confirmed with a homozygous or heterozygous deletion of SMN1 • *12 years and older • Treatment with SMN- modulator

Exclusion criteria

Exclusion criteria: Strong apprehension against the performance of EMG of any kind

Design outcomes

Primary

Measure	Time frame
Part 1 CMAP (APB (median nerve)) CMAP scan (APB (median nerve)) Excitability testing (APB (median nerve)) H-reflex (FCR (median nerve)) RNS (3Hz at APB (median nerve) and trapezoid (n accesorius); 50Hz at APB (median nerve)) SNAP (median/radial/ulnar nerve, sural nerve) Part 2 CMAP scan (APB (median nerve)) SNAP (median nerve, sural nerve) Excitability testing (APB (median nerve))	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results