'Post-traumatic stress disorder' and 'Stress disorder'
Conditions
Interventions
Participants in both conditions will receive the same intensive TFT lasting 8
days within 2 consecutive weeks, in which daily TFT-sessions, PE and EMDR
therapy, and psycho-education are combined. Th
Sponsors
PSYTREC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, subjects must meet all of the following criteria: (1) a diagnosis of PTSD based on the Clinician-Administered PTSD Scale (CAPS-5), (2) being at least 18 years old (3) sufficient knowledge of the Dutch language to undergo treatment.
Exclusion criteria
Exclusion criteria: Potential subjects who meet any of the following criteria will be excluded from participation in this study: (1) a suicide attempt less than three months prior to treatment, (2) being medically unfit to participate in the physical activity intervention operationalized as not being able to walk for at least 30 minutes (e.g., physical impairments that necessitate the use of wheelchair).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the change in PTSD symptoms from pre- to posttreatment and at 6-month follow-up, measured with the Clinician-Administered PTSD Scale (CAPS-5) and the PTSD Checklist for DSM-5 (PCL-5). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures are the underlying biological and psychological mediators, measured with the Cortisol Awakening Response (CAR), inflammation levels, DNA methylation, Insomnia Severity Index (ISI), Depressive Symptomatology Self-Report (QIDS-SR), Difficulties in Emotion Regulation Scale (DERS), Dissociative Experiences Scale-II (DES-II), and the Anxiety Sensitivity Index (ASI). | — |
Countries
Netherlands
Outcome results
None listed