toxicology study of the adverse effects of chemical substances on living organisms toxicology
Conditions
Interventions
0.1875 *g/kg b.w. of ZEN (i.e. 75% of the tolerable daily intake) as oral bolus
in water.
Sponsors
Wageningen Food Safety Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Healthy subjects (self-reported), aged 18-65 years.
Exclusion criteria
Exclusion criteria: * Subjects with a BMI of 18.5 kg/m2 and below, or 30 kg/m2 and above. * Subjects using prescribed medication during the duration of the study. * Pregnant women or women intending to become pregnant during the duration of the study. * Breastfeeding women. * Women menstruating at the anticipated days of sample collection. * Intestinal, liver, biliary, or kidney disease, ileostomy, chronic diarrhea, chronic constipation, celiac disease * Occupation: working in or frequently visiting (>2d/week) grain silos or flour factories. * Working at WFSR.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentrations of ZEN biomarkers (ZEN, *-ZEL, and *-ZEL, measured after enzymatic deconjugation) excreted in urine over ~72h after ingestion of a single dose of ZEN. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed