Corona virus COVID-19
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Three groups of women will be eligible for inclusion in this pilot study: 1. COVID-19 during pregnancy: severe or critical disease 2. COVID-19 during pregnancy: mild disease 3. Healthy pregnant controls 4. COVID-19: non-pregnant women (from BEAT-COVID-1 study) Mild, severe and critical disease are classified using the definitions of the WHO (WHO: Clinical management of severe acute respiratory infection when COVID-19 is suspected, March 13, 2020): -mild disease: hospital interventions is not required, only symptomatic treatment (such as antipyretics for fever) and monitoring -severe disease: hospitalization and oxygen therapy is required -critical disease: acute respiratory distress syndrome (ARDS), advanced oxygen/ventilatory support is required Inclusion criteria group 1 - Laboratory confirmation of SARS-CoV-2 infection - Severe or critical disease Group 2: - Laboratory confirmation of SARS-CoV-2 infection - Mild disease - Similar maternal age and gestational age as one of the patients in group 1 (matched as accurately as possible) Group 3: - Similar maternal age and gestational age as one of the patients in group 1 (matched as accurately as possible)
Exclusion criteria
Exclusion criteria: NA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune composition(B cell and plasma cell subsets, small clonal B cell populations, innate cells, T cell subsets, cytokine profile; using the EuroFlow panel and Luminex assay) | — |
Countries
Netherlands
Outcome results
None listed