insulin resistance Metabolic syndrome
Conditions
Interventions
During each test day, participants will receive a drink with potassium nitrate
(KNO3) providing a total of 10 mmol (625 mg) of inorganic nitrate or an
isomolar solution of potassium chloride (KCl) a
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Men - Aged between 18 - 60 years - Waist circumference minimal 102 cm (abdominally obese) - Fasting plasma glucose * 7.0 mmol/L - Fasting serum total cholesterol * 8.0 mmol/L - Systolic blood pressure
Exclusion criteria
Exclusion criteria: - Women - Left-handedness - Current smoker, or smoking cessation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the acute effect of inorganic nitrate as compared with placebo on the acute effect of inorganic nitrate as compared with placebo on brain insulin-sensitivity, as assessed by the gray-matter CBF response to intranasally administered insulin using MRI ASL. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the acute effects of inorganic nitrate as compared with a placebo on brain vascular function, as assessed by CBF. Additionally, the effect of brain insulin-sensitivity changes on cognitive performance in the domain of executive function and spatial memory will be investigated using CANTAB, after consumption of nitrate as compared with placebo | — |
Countries
Netherlands
Outcome results
None listed