Cardiovascular disease
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Participant in 300OB cohort, so all have a BMI> 27 and age >18 years -Males -Written informed consent -4 weeks prior to inclusion stop cholesterol lowering drugs such as: statins
Exclusion criteria
Exclusion criteria: -Inability to personally provide written informed consent (e.g. for linguistic or mental reasons) -Documented bleeding diathesis or thrombocytopenia 38.5) -Previous vaccination within 1 months prior to study entry -Chronic use of anti-inflammatory drugs such as NSAIDs (acetylsalicylic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The most important question is whether there is trained immunity in the bone marrow progenitor cells of the subjects with the metabolic syndrome compared to subjects without metabolic syndrome. | — |
Secondary
| Measure | Time frame |
|---|---|
| The two other study parameters are 1) whether there are characteristics of trained immunity in the circulating monocytes, and 2) whether there is heterogeneity in the circulating monocytes with respect to the trained phenotype. | — |
Countries
Netherlands
Outcome results
None listed