malignant meningitis neoplasttic meningitis
Conditions
Interventions
None listed
Sponsors
Neurologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients who have a clinical indication for a diagnostic lumbar puncture because of secondary malignancy of the CNS (leptomeningeal metastases and/ or brain metastases) : 1/ age >18 years 2/ able and willing to give written consent 3/ able and willing to undergo lumbar puncture and venipuncture
Exclusion criteria
Exclusion criteria: 1/ if contra-indications for lumbar puncture are present -skin infection -coagulopathy -signs or symptoms of increased intracranial pressure -midline shift or obliteration of basal cisterns on neuro-imaging 2/ if a patient is unable or unwilling to give written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of CSF / blood samples in which successful mutation analysis can be performed by liquid biopsy The number and nature of additional mutations in CSF-ct DNA relative to blood and (if available) solid material of primary tumor Relevant mutations concern mutations involved in therapy resistance and / or new targetable therapies, as described in (dynamic) online databases such as www.pharmgk.org or www.cpct.nl | — |
Secondary
| Measure | Time frame |
|---|---|
| - comparison between liquid biopsy findings in CSF versus routine parameters in CSF and / or radiological parameters, currently used for the diagnosis of leptomeningeal metastases - correlation between CSF-ct DNA amount and specific mutations with clinical course and survival data - course of tumor mutations over time, when there is a clinical indication for repeated lumbar punctures, and relationship of these mutations to the patient's neurological condition and therapy future research goals - detection of specific adhesion molecules or chemokines that play a role in the trophism of solid CNS tumors - detection of new targetable mutations by dd-PCR. | — |
Countries
Netherlands
Outcome results
None listed