Alzheimer's Disease Inheritable Dementia
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Potential subjects need to have a dominantly inherited Alzheimer's Disease (DIAD) mutation and must be at least 18 years of age.
Exclusion criteria
Exclusion criteria: Participants who show dementia due to (familial) AD will be excluded from the study. In addition, participants who have for example cardiac pacemakers, ICD's or other intracorporal devices which excessively interfer with MEG-signals may be excluded. Additional contra-indications for MRI scanning (e.g. implanted metals), current or planned pregnancy and subjects with severe claustrophobia cannot participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hippocampal and global brain MEG based measures of oscillatory brain activity, represented in total broadband power and E/I balance (from 1/f of the powerspectrum or new method for fE/I, based on DFA and power. | — |
Secondary
| Measure | Time frame |
|---|---|
| MEG-based measures of: - oscillatory activity, represented in (average) peak frequency and relative power of the following frequency bands: theta (4-8 Hz), alpha (8*13 Hz), beta (13-30 Hz), and gamma (30-48Hz). - functional connectivity between target regions in specific frequency bands, expressed as amplitude envelope correlation corrected (AECc) for volume conduction. - functional network measures by the use of graph theoretical measures, including degree, modularity, path length, betweenness centrality. Structural MRI: - Structural connectome - Grey & White matter volumes - White matter integrity & microbleeds Neuropsychological performance - Scores from different tests will be used as indices of cognitive performance on different domains - Score of the working memory task during the MEG recording will be used as indicator for working memory | — |
Countries
Netherlands
Outcome results
None listed