In vitro human preimplantation embryo development in an adapted culture system based on human uterine fluid composition and uterine pH.

In vitro human preimplantation embryo development in an adapted culture system based on human uterine fluid composition and uterine pH. - Embryo culture in four different culture media

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49697

Enrollment

700

Registered

2020-03-22

Start date

2022-02-12

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subfertiliteit infertility subfertility

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Vital thawed human left-over preimplantation embryos, consisting of a minimum of 5 blastomeres that comprise >=50% of the whole embryo, that were donated for research.

Exclusion criteria

Exclusion criteria: Of all human left-over day 3 or 4 embryos that were donated for research: embryos that did not survive the freeze-thawing procedure or embryos that consist of less than 5 blastomeres and/or are less than 50% vital.

Design outcomes

Primary

Measure	Time frame
The primary outcome is the blastocyst formation rate.	—

Secondary

Measure	Time frame
Secondary outcomes are embryo quality based on morphological assessment and cell count, embryo metabolism, embryo gene expression, and embryo methylation pattern.	—

Countries

Netherlands

Outcome results