MICrobiota, KEY between Mother and Offspring USsing SEquencing techniques

MICrobiota, KEY between Mother and Offspring USsing SEquencing techniques - MICKEY MOUSE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49693

Enrollment

150

Registered

2020-05-08

Start date

2021-05-03

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NEC necrotising enterocolitis

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: preterm children born before 30 weeks' gestational age, and/or birth weights below 1000 grams.

Exclusion criteria

Exclusion criteria: Other abdominal diseases, e.g. abdominal wall defects or congenital intestinal atresias.

Design outcomes

Primary

Measure	Time frame
Development of necrotising enterocolitis	—

Secondary

Measure	Time frame
Neonatal: fecal microbiota, fecal human DNA methylation pattern (shedded enterocytes and lymphocytes), fecal bile salts acids, fecal SCFA and iAF, iAF expression in the margins of the resection specimens, urine metabolome, cerebral and intestinal tissue oxygen saturation (as measured with NIRS), peak systolic flow velocity and the mean end-diastolic flow velocity of the superior mesenteric artery and a branch of the medial cerebral artery assessment using Echo Doppler, serum IMA, serum (i)AF, T1/T2 cytokine ratio in umbilical cord blood, iAF in resection specimens Mother: microbiota in mother*s milk, vaginal, perineal and rectal microbiota; amnionic fluid in case of caesarian,validated diet questionnaire ('Wat een Nederland' questionnaire as used by RIVM)	—

Measure

Time frame

Neonatal: fecal microbiota, fecal human DNA methylation pattern (shedded enterocytes and lymphocytes), fecal bile salts acids, fecal SCFA and iAF, iAF expression in the margins of the resection specimens, urine metabolome, cerebral and intestinal tissue oxygen saturation (as measured with NIRS), peak systolic flow velocity and the mean end-diastolic flow velocity of the superior mesenteric artery and a branch of the medial cerebral artery assessment using Echo Doppler, serum IMA, serum (i)AF, T1/T2 cytokine ratio in umbilical cord blood, iAF in resection specimens Mother: microbiota in mother*s milk, vaginal, perineal and rectal microbiota; amnionic fluid in case of caesarian,validated diet questionnaire ('Wat een Nederland' questionnaire as used by RIVM)

—

Countries

Netherlands

Outcome results