Cognitive rehabilitation treatment (CRT) in patients with bipolar disorder and cognitive problems.

Cognitive rehabilitation treatment (CRT) in patients with bipolar disorder and cognitive problems. - CRT with bipolar disorder and cognitive problems.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON49678

Enrollment

Registered

2020-12-16

Start date

2020-01-01

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolar disorder and manic-depression

Interventions

CRT is made freely available (Boom, 2010) (https://www.boompsychologie.nl/productgroep/101-15_Neuropsychologie#downloads). The CRT is offered individually to a patient. It is applied to a specific

1) psychoeducation, 2) goal setting and planning, and 3) implementation. CRT can be aimed at improving executive functioning, memory problems or problems with time constraints. Treatment is adapted

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - primair classification is bipolar disorder - presence of cogntive problems in the neuropsychological profile - patiënt are in the euthymic phase - treatment with medication is stable.

Exclusion criteria

Exclusion criteria: - a depressive, hypomanic or manic phase - no objective cognitive problems

Design outcomes

Primary

Measure	Time frame
The primary outcome of "subjective complaints" is measured with the Cognitive Failure Questionnaire (CFQ) (Broadbent, Cooper, FitzGerald & Parkes, 1982). The CFQ (appendix 1) is a self-report questionnaire in which patients indicate the number of mistakes made regarding their cognitive impairment (e.g., forgetting names). The questionnaire contains 25 items measured with a 5-point scale (0 = never to 4 = always), with a range from 0 to 100. The CFQ has good psychometric qualities, including test-retest reliability (Ponds, van Boxtel & Jolles, 2006) and reliability (Bridger, Johnsen & Brasher, 2013). A higher score on the CFQ indicates more subjective cognitive symptoms than a lower score on the CFQ. Significant differences between thee CFQ score at T1 and T0 will be examined.	—

Measure

Time frame

The primary outcome of "subjective complaints" is measured with the Cognitive Failure Questionnaire (CFQ) (Broadbent, Cooper, FitzGerald & Parkes, 1982). The CFQ (appendix 1) is a self-report questionnaire in which patients indicate the number of mistakes made regarding their cognitive impairment (e.g., forgetting names). The questionnaire contains 25 items measured with a 5-point scale (0 = *never* to 4 = *always*), with a range from 0 to 100. The CFQ has good psychometric qualities, including test-retest reliability (Ponds, van Boxtel & Jolles, 2006) and reliability (Bridger, Johnsen & Brasher, 2013). A higher score on the CFQ indicates more subjective cognitive symptoms than a lower score on the CFQ. Significant differences between thee CFQ score at T1 and T0 will be examined.

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Secondary

Measure	Time frame
The objective cognitive symptoms are measured by a short neuropsychological examination (NPO), in which attention and concentration, verbal learning and memory, and executive functioning are measured. The scores on this neuropsychological assessment are subsequently classified as no neurocognitive problems (greater than or equal to the 20th percentile), "deficit" (between the 2.4th-20th percentile) or "impairment" (less than the 2.4th percentile) (Lezak, Howiesan, & Loring, 2012). At T0, the Digit Series subtest and the Symbol Substitution subtest of the Wechsler Adult Intelligence Scale (WAIS-IV-NL; Wechsler, 2012) are administered and measure working memory and processing speed, respectively. The Tower Test of the D-KEFS is used to measure executive functioning (Delis et al, 2001). The 15-word test is used to measure verbal memory and learning ability (15WT; Kalverboer & Deelman, 1986). The d2 is used to measure sustained attention (Brickenkamp, 2002). The psychometric qualities of these tests are sufficient to good and can be found in the test manuals (Brickenkamp, 2002; "Delis et al., 2001; Kalverboer & Deelman, 1986; Wechsler, 2012). This neuropsychological assessment is repeated after completion of CRT at T1.	—

Measure

Time frame

The objective cognitive symptoms are measured by a short neuropsychological examination (NPO), in which attention and concentration, verbal learning and memory, and executive functioning are measured. The scores on this neuropsychological assessment are subsequently classified as *no neurocognitive problems* (greater than or equal to the 20th percentile), "deficit" (between the 2.4th-20th percentile) or "impairment" (less than the 2.4th percentile) (Lezak, Howiesan, & Loring, 2012). At T0, the Digit Series subtest and the Symbol Substitution subtest of the Wechsler Adult Intelligence Scale (WAIS-IV-NL; Wechsler, 2012) are administered and measure working memory and processing speed, respectively. The Tower Test of the D-KEFS is used to measure executive functioning (Delis et al, 2001). The 15-word test is used to measure verbal memory and learning ability (15WT; Kalverboer & Deelman, 1986). The d2 is used to measure sustained attention (Brickenkamp, 2002). The psychometric qualities of these tests are sufficient to good and can be found in the test manuals (Brickenkamp, 2002; "Delis et al., 2001; Kalverboer & Deelman, 1986; Wechsler, 2012). This neuropsychological assessment is repeated after completion of CRT at T1.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)