Improving cognitive performance in MS by transcranial alternating current brain stimulation (tACS): a pilot study

Improving cognitive performance in MS by transcranial alternating current brain stimulation (tACS): a pilot study - Cognitive function in MS after tACS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49662

Enrollment

Registered

2017-06-19

Start date

2017-11-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitive impairment MS nervous system

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: MS Patients: Diagnosis of MS according to the MacDonald criteria Age: 30 - 60 years Cognitive impairment (CI): CI patients will have decreased values (1.5 standard deviations below the normative control values or below cut-off value for deviation) on at least 2 tests from NPE battery. Signed written informed consent and right handedness. Healthy participants: Age: 30 - 60 years Signed written informed consent and right handedness.

Exclusion criteria

Exclusion criteria: 1. History of psychiatric or neurological illness other than MS for MS patients or History of psychiatric or neurological illness for healthy participants 2. Metal implants (e.g., pacemaker, heart valves, vascular clips, eye-implants, copper containing intra-uterine devices, non-removable piercing, cerebral implants) 3. Any risk of having metal particles in the eyes 4. Tattoos containing iron oxide (often found in red pigments) 5. (Suspected) Pregnancy or breast feeding 6. Claustrophobia 7. Alcohol or drug abuse 8. Excessive intake of coffee (>5 units per day) or alcohol (>2 units per day); 9. Recent use of alcohol (2 days before the EEG and/or fMRI measurement). 10. Recent use (within one week) of cannabis, benzodiazepine, baclofen or any other nonprescription psychopharmaca; 11. Refusal to be informed of structural brain abnormalities that could be detected during the experiment 12. Diagnosis of epilepsy, Parkinson*s disease, Myasthenia Gravis, epilepsy and dementia. 13. Severe scalp skin lesions 14. Color blindness

Design outcomes

Primary

Measure	Time frame
The changes in EEG coherence and in speed of information processing in patients with MS using tACS. EEG coherence will be estimated between frontal and parietal regions from RS EEG recordings. The information processing speed will be measured using the Vienna Reaction Time Task (VRTT).	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results