alcohol use disorder alcoholic liver disease
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - diagnosis of ALD - age>18 years old - validation cohort:reliable self-reported alcohol use. The reliability of this self-report will be based on (1) an interview by the researcher at study inclusion, (2) an interview by the physician at inclusion. - clinical application group: patients with ALD who deny moderate or excessive alcohol intake in the last three months
Exclusion criteria
Exclusion criteria: - Other liver disease than ALD: more concrete: viral hepatitis, auto-immune liver disease, hereditary hemochromatosis, Wilson's disease, cholestatic liver diseases (primary biliary cholangitis, primary sclerosing cholangitis) en *1- antitrypsine deficiency. - unreliable self-reported alcohol use - Pregnancy and breastfeeding - Incompetent to understand and/or sign the informed consent - Unwilling to provide biosamples
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify, develop and validate non-invasive biomarkers in blood, scalp hair, fingernails and urine for the assessment of alcohol use in patients with ALD with and without cirrhosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify the effect of liver cirrhosis and alcoholic liver disease on the diagnostic accuracy of non-invasive biomarkers for the assessment of alcohol use in patients with ALD. Identify, develop and validate future non-invasive biomarkers for the assessment of alcohol use in patients with ALD. To obtain body samples from patients with ALD for translational studies on the pathophysiology and treatment of ALD, with a focus on the gut-liver axis, this includes blood, exhaled air, urine, stools and optionally, when endoscopy is part of standard care, also intestinal biopsy samples | — |
Countries
Netherlands
Outcome results
None listed