biologische markers depression Major depressive disorders
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient is eligble for participation when he/she: 1) will start neuromodulation treatment or psychotherapy (behavioural activation) at the AMC, department of Psychiatry, mood disorders; 2) has not started the treatment yet; 3) is diagnosed with a unipolar depressive disorder; 4) is older than 18 years.
Exclusion criteria
Exclusion criteria: Co-morbid psychiatric disorders are accepted, except for schizophrenia, psychosis, and unstable high risk patients with acute hightened risk of suicide. If the main diagnosis of MDD is missing, the patient is not eligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the relationship between change in depressive symptomatology with change in microbioom compositions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are relationships between change in depressive symptoms and changes in other biological and psychological markers, including oral microbiota, blood serum, ecological momentary assessment, and psychological questionnaires. | — |
Countries
Netherlands
Outcome results
None listed